The non‐human primate model of tuberculosis
Identifieur interne : 001351 ( Main/Exploration ); précédent : 001350; suivant : 001352The non‐human primate model of tuberculosis
Auteurs : D. Kaushal [États-Unis] ; S. Mehra [États-Unis] ; P. J. Didier [États-Unis] ; A. A. Lackner [États-Unis]Source :
- Journal of Medical Primatology [ 0047-2565 ] ; 2012-06.
English descriptors
- Teeft :
- Aerosol route, Aids pathogenesis, Bigbee, Candidate vaccines, Caseous, Caseous lesion, Caseous lesions, Chen, Coinfection, Cynomolgus, Cynomolgus macaques, Disease progression, Erdman, Erdman strain, Experimental models, Flynn, Granuloma, Granulomatous lesions, Guinea pigs, High dose, Huang, Human disease, Immun, Immune, Infection, Infectious diseases, Intratracheal, John wiley sons, Kaushal, Klein, Latent infection, Latent mycobacterium tuberculosis infection, Latent tuberculosis, Lesion, Letvin, Macaca, Macaca mulatta, Macaque, Macaque model, Mutant, Mycobacterium, Mycobacterium tuberculosis, Mycobacterium tuberculosis infection, Nhps, Nonhuman, Nonhuman primate model, Nonhuman primates, Pathogen, Pathogenesis, Plo, Plos pathog, Preclinical testing, Primate, Primate model, Primate research center, Primates, Primatol, Proc natl acad, Reactivation, Rhesus, Rhesus macaques, Shen, Simian, Simian virus, Tuberculosis, Tulane, Vaccine.
Abstract
Non‐human primates (NHPs) are used to model human disease owing to their remarkably similar genomes, physiology, and immune systems. Recently, there has been an increased interest in modeling tuberculosis (TB) in NHPs. Macaques are susceptible to infection with different strains of Mycobacterium tuberculosis (Mtb), producing the full spectrum of disease conditions, including latent infection, chronic progressive infection, and acute TB, depending on the route and dose of infection. Clearly, NHPs are an excellent model of human TB. While the initial aim of the NHP model was to allow preclinical testing of candidate vaccines and drugs, it is now also being used to study pathogenesis and immune correlates of protection. Recent advances in this field are discussed in this review. Key questions such as the effect of hypoxia on the biology of Mtb and the basis of reactivation of latent TB can now be investigated through the use of this model.
Url:
DOI: 10.1111/j.1600-0684.2012.00536.x
Affiliations:
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Kaushal</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Bacteriology & Parasitology, Tulane National Primate Research Center, Covington, LA</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Microbiology & Immunology, Tulane University School of Medicine, New Orleans, LA</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Mehra, S" sort="Mehra, S" uniqKey="Mehra S" first="S." last="Mehra">S. 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Lackner</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Microbiology & Immunology, Tulane University School of Medicine, New Orleans, LA</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Primatology</title><title level="j" type="alt">JOURNAL OF MEDICAL PRIMATOLOGY</title><idno type="ISSN">0047-2565</idno><idno type="eISSN">1600-0684</idno><imprint><biblScope unit="vol">41</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="191">191</biblScope><biblScope unit="page" to="201">201</biblScope><biblScope unit="page-count">11</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2012-06">2012-06</date></imprint><idno type="ISSN">0047-2565</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0047-2565</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Aerosol route</term><term>Aids pathogenesis</term><term>Bigbee</term><term>Candidate vaccines</term><term>Caseous</term><term>Caseous lesion</term><term>Caseous lesions</term><term>Chen</term><term>Coinfection</term><term>Cynomolgus</term><term>Cynomolgus macaques</term><term>Disease progression</term><term>Erdman</term><term>Erdman strain</term><term>Experimental models</term><term>Flynn</term><term>Granuloma</term><term>Granulomatous lesions</term><term>Guinea pigs</term><term>High dose</term><term>Huang</term><term>Human disease</term><term>Immun</term><term>Immune</term><term>Infection</term><term>Infectious diseases</term><term>Intratracheal</term><term>John wiley sons</term><term>Kaushal</term><term>Klein</term><term>Latent infection</term><term>Latent mycobacterium tuberculosis infection</term><term>Latent tuberculosis</term><term>Lesion</term><term>Letvin</term><term>Macaca</term><term>Macaca mulatta</term><term>Macaque</term><term>Macaque model</term><term>Mutant</term><term>Mycobacterium</term><term>Mycobacterium tuberculosis</term><term>Mycobacterium tuberculosis infection</term><term>Nhps</term><term>Nonhuman</term><term>Nonhuman primate model</term><term>Nonhuman primates</term><term>Pathogen</term><term>Pathogenesis</term><term>Plo</term><term>Plos pathog</term><term>Preclinical testing</term><term>Primate</term><term>Primate model</term><term>Primate research center</term><term>Primates</term><term>Primatol</term><term>Proc natl acad</term><term>Reactivation</term><term>Rhesus</term><term>Rhesus macaques</term><term>Shen</term><term>Simian</term><term>Simian virus</term><term>Tuberculosis</term><term>Tulane</term><term>Vaccine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Non‐human primates (NHPs) are used to model human disease owing to their remarkably similar genomes, physiology, and immune systems. Recently, there has been an increased interest in modeling tuberculosis (TB) in NHPs. Macaques are susceptible to infection with different strains of Mycobacterium tuberculosis (Mtb), producing the full spectrum of disease conditions, including latent infection, chronic progressive infection, and acute TB, depending on the route and dose of infection. Clearly, NHPs are an excellent model of human TB. While the initial aim of the NHP model was to allow preclinical testing of candidate vaccines and drugs, it is now also being used to study pathogenesis and immune correlates of protection. Recent advances in this field are discussed in this review. Key questions such as the effect of hypoxia on the biology of Mtb and the basis of reactivation of latent TB can now be investigated through the use of this model.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Louisiane</li></region></list><tree><country name="États-Unis"><region name="Louisiane"><name sortKey="Kaushal, D" sort="Kaushal, D" uniqKey="Kaushal D" first="D." last="Kaushal">D. Kaushal</name></region><name sortKey="Didier, P J" sort="Didier, P J" uniqKey="Didier P" first="P. J." last="Didier">P. J. Didier</name><name sortKey="Kaushal, D" sort="Kaushal, D" uniqKey="Kaushal D" first="D." last="Kaushal">D. Kaushal</name><name sortKey="Lackner, A A" sort="Lackner, A A" uniqKey="Lackner A" first="A. A." last="Lackner">A. A. Lackner</name><name sortKey="Lackner, A A" sort="Lackner, A A" uniqKey="Lackner A" first="A. A." last="Lackner">A. A. Lackner</name><name sortKey="Mehra, S" sort="Mehra, S" uniqKey="Mehra S" first="S." last="Mehra">S. Mehra</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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